Hot Topic: [Calorie Restriction Mimetics (Guest Editor: Marios Kyriazis)]

The Benefits of Calorie Restriction and Calorie Restriction Mimetics as Related to the Eye.

The effects of calorie restriction without malnutrition seem to possess many beneficial effects in numerous disease states. Recently, studies related to calorie restriction mimetics that biochemically mimic the effects of calorie restriction are also becoming increasingly popular. Both calorie restriction and calorie restriction mimetics trigger an adaptive response reminiscent of mild-stress o...

Glycolytic inhibition as a strategy for developing calorie restriction mimetics.

Calorie restriction (CR) remains the most robust environmental intervention for altering aging processes and increasing healthspan and lifespan. Emerging from progress made in many nonhuman models, current research has expanded to formal, controlled human studies of CR. Since long-term CR requires a major commitment of will power and long-term negative consequences remain to be determined, the ...

Calorie Restriction Mimetics: Examples and Mode of Action

The search for Calorie Restriction Mimetics (CRM) compounds that mimic the genetic, biochemical and physical actions of calorie restriction is not a search for a ‘lazy dieters pill’. It is a quest aiming to clarify the basic mechanisms of calorie restriction and develop strategies in order to prevent, treat or alleviate age-related conditions. The development of CRM will add new and important a...

Guest Editor\'s Note

Although Occupational Therapy in Iran is relatively a new profession, it has been well progressed, providing various services for people with all kinds of disabilities. As such, in the last decades, OT has been recognized as the major demand in all governmental, private and NGO sectors. Due to this demand, occupational therapy training programs have been increased from three into ten, expecting...

Calorie Restriction, Longevity and Cognitive Function